PF-04937319 |
| Catalog No.GC36881 |
PF-04937319 es un activador de la glucoquinasa (GKA) con un valor de EC50 de 154,4 μM, una de las estrategias mÁs prometedoras para el tratamiento de la diabetes mellitus tipo 2.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1245603-92-2
Sample solution is provided at 25 µL, 10mM.
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PF-04937319 is a glucokinase activator (GKA) with EC50 value of 154.4 μM, one of the most promising strategies for the treatment of type 2 diabetes mellitus[1].PF-04937319 is designed to maintain glucose-lowering efficacy while mitigating the risk of hypoglycaemia observed with many other GKAs[2]. EC50: 154.4 μM (GSA) (PF-04937319)[1]
[1]. Dzyurkevich MS, et al. Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus. Sci Rep. 2017 Nov 22;7(1):16072. [2]. Amin NB, et al. Two dose-ranging studies with PF-04937319, a systemic partial activator of glucokinase, as add-on therapy to metformin in adults with type 2 diabetes. Diabetes Obes Metab. 2015 Aug;17(8):751-9.
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