SSR 149415 |
| Catalog No.GC50376 |
Potent and selective vasopressin V1B antagonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 439687-69-1
Sample solution is provided at 25 µL, 10mM.
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Potent and selective vasopressin V1B antagonist (Ki values are 3.7 and 1.3 nM for native and recombinant rat V1b receptors, respectively). Displays >70-fold selectively for rat V1B over V1A, V2 oxytoxin and a range of other receptors and ion channels. Inhibits AVP-induced glucagon release in In-R1-G9 α-pancreatic cells in vitro. Inhibits stress-induced ACTH release and exhibits anxiolytic-like effects in anxiety models. Orally bioavailable.
Serradeil-Le Gal et al (2005) An overview of SSR149415, a selective nonpeptide vasopressin V1b receptor antagonist for the treatment of stress-related disorders. CNS Drug Rev. 11 53 PMID:15867952
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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