ASLAN003 (Synonyms: ASLAN003) |
| Catalog No.GC38463 |
ASLAN003 (ASLAN003) es un potente inhibidor de la dihidroorotato deshidrogenasa (DHODH) activo por vÍa oral con una IC50 de 35 nM para la enzima DHODH humana. ASLAN003 inhibe la sÍntesis de proteÍnas mediante la activaciÓn de factores de transcripciÓn AP-1. ASLAN003 induce la apoptosis y prolonga sustancialmente la supervivencia en ratones con xenoinjerto de leucemia mieloide aguda (AML).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1035688-66-4
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
ASLAN003 is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) which has the potential to be a first-in-class candidate in AML (Acute Myelogenous Leukemia). ASLAN003 has antitumor activity[1].
[1]. Marco L. Lolli, et al. Human Dihydroorotate Dehydrogenase (hDHODH) as a new target on Acute Myelogenous Leukemia (AML): Targeting Myeloid Differentiation using Potent and Innovative hDHODH Inhibitors. 23rd Swedish Conference on Macromolecular Structure and Function TÄllberg, 14-17 June 2019
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *