Dooku1 |
| Catalog No.GC38553 |
Dooku1, un anÁlogo de Yoda1, es un antagonista selectivo del canal Piezo1 endÓgeno.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2253744-54-4
Sample solution is provided at 25 µL, 10mM.
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Dooku1, an analog of Yoda1, is a selective antagonist of the endogenous Piezo1 channel. Dooku1 inhibited 2 μM Yoda1-induced Ca2+-entry with IC50 values of 1.3 μM (in HEK 293 cells) and 1.5 μM (in HUVECs). Dooku1 inhibits Yoda1-induced relaxation of aorta[1].
[1]. Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175(10):1744-1759.
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