Gentisuric Acid |
Catalog No.GD13954
One-Click Copy Product Info
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Gentisuric acid tiene la fórmula molecular C₉H₉NO₅, un peso molecular de 211.17, y su nombre químico es N-(2,5-dihydroxybenzoyl) glicina. Gentisuric acid es un metabolito del ácido salicílito o la aspirina y sirve como sustrato para la α-amidomonooxygenase (PAM), Gentisuric acid tiene la capacidad de aliviar el daño del DNA inducido por la mitomicina C
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 25351-24-0
Sample solution is provided at 25 µL, 10mM.
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Gentisuric acid tiene la fórmula molecular C₉H₉NO₅, un peso molecular de 211.17, y su nombre químico es N-(2,5-dihydroxybenzoyl) glicina[1]. Gentisuric acid es un metabolito del ácido salicílito o la aspirina y sirve como sustrato para la α-amidomonooxygenase (PAM), Gentisuric acid tiene la capacidad de aliviar el daño del DNA inducido por la mitomicina C[2]. Como derivado del uric acid, gentisuric acid juega un papel importante en el metabolismo de la purina y a menudo se utiliza para estudiar sus posibles efectos terapéuticos en la gota y otras enfermedades relacionadas con los niveles de uric acid [3].
References:
[1] DeBlassio JL, deLong MA, Glufke U, et al. Amidation of salicyluric acid and gentisuric acid: a possible role for peptidylglycine alpha-amidating monooxygenase in the metabolism of aspirin. Arch Biochem Biophys. 2000 Nov 1;383(1):46-55.
[2] Niikawa M, Shin S, Nagase H. Suppressive effect of post- or pre-treatment of aspirin metabolite on mitomycin C-induced genotoxicity using the somatic mutation and recombination test in Drosophila melanogaster. Biomed Pharmacother. 2007 Feb-Apr;61(2-3):113-9.
[3] Wilson JT, Howell RL, Holladay MW, et al. Gentisuric acid: metabolic formation in animals and identification as a metabolite of aspirin in man. Clin Pharmacol Ther. 1978 Jun;23(6):635-43.
| Cas No. | 25351-24-0 | SDF | |
| Formula | C9H9NO5 | M.Wt | 211.17 |
| Solubility | Storage | Store at 2-8°C | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.7355 mL | 23.6776 mL | 47.3552 mL |
| 5 mM | 947.1 μL | 4.7355 mL | 9.471 mL |
| 10 mM | 473.6 μL | 2.3678 mL | 4.7355 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)