Gentisuric Acid |
Catalog No.GD13954
One-Click Copy Product Info
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Gentisuric acid의 분자식은 C₉H₉NO₅이고 분자량은 211.17이고 화학명은 N - (2,5 - dihydroxybenzoyl) glycine이다. Gentisuric acid는 살리실 산나 아스피린의 대사 산물이고 α - amidomonooxygenase (PAM)의 기질이고 Gentisuric acid는 mitomycin C에 의해 유도된 DNA 손상을 완화할 수 있는 능력이 있다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 25351-24-0
Sample solution is provided at 25 µL, 10mM.
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Gentisuric acid의 분자식은 C₉H₉NO₅이고 분자량은 211.17이고 화학명은 N - (2,5 - dihydroxybenzoyl) glycine이다. Gentisuric acid는 살리실 산나 아스피린의 대사 산물이고 α - amidomonooxygenase (PAM)의 기질이고 Gentisuric acid는 mitomycin C에 의해 유도된 DNA 손상을 완화할 수 있는 능력이 있다. 유리산의 유도체인 Gentisuric acid는 퓨린 대사에서 중요한 역할을 하고 요산 수치와 관련된 통풍 및 기타 질병에 대한 잠재적인 치료 효과를 연구할 때 종종 사용된다[3].
References:
[1] DeBlassio JL, deLong MA, Glufke U, et al. Amidation of salicyluric acid and gentisuric acid: a possible role for peptidylglycine alpha-amidating monooxygenase in the metabolism of aspirin. Arch Biochem Biophys. 2000 Nov 1;383(1):46-55.
[2] Niikawa M, Shin S, Nagase H. Suppressive effect of post- or pre-treatment of aspirin metabolite on mitomycin C-induced genotoxicity using the somatic mutation and recombination test in Drosophila melanogaster. Biomed Pharmacother. 2007 Feb-Apr;61(2-3):113-9.
[3] Wilson JT, Howell RL, Holladay MW, et al. Gentisuric acid: metabolic formation in animals and identification as a metabolite of aspirin in man. Clin Pharmacol Ther. 1978 Jun;23(6):635-43.
| Cas No. | 25351-24-0 | SDF | |
| Formula | C9H9NO5 | M.Wt | 211.17 |
| Solubility | Storage | Store at 2-8°C | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.7355 mL | 23.6776 mL | 47.3552 mL |
| 5 mM | 947.1 μL | 4.7355 mL | 9.471 mL |
| 10 mM | 473.6 μL | 2.3678 mL | 4.7355 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)