GSK2646264 |
| Catalog No.GC64889 |
GSK2646264 (Compuesto 44) es un inhibidor potente y selectivo de la tirosina quinasa del bazo (SYK) con una pIC50 de 7,1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1398695-47-0
Sample solution is provided at 25 µL, 10mM.
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GSK2646264 (Compound 44) is a potent and selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.1. GSK2646264 also inhibits other kinases with pIC50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 against LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B and Aurora A, respectively. GSK2646264 is penetrable into the epidermis and dermis of the skin[1].
[1]. Barker MD, et al. Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease. Bioorg Med Chem Lett. 2018 Nov 15;28(21):3458-3462.
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