Guanabenz (Synonyms: GBZ, GA, Wytensin, Wy-8678,BR-750) |
| Catalog No.GC25484 |
Guanabenz (GBZ, GA, Wytensin, Wy-8678,BR-750) is an orally active central alpha 2-adrenoceptor (α2 adrenergic receptor) agonist with antihypertensive action.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 5051-62-7
Sample solution is provided at 25 µL, 10mM.
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Guanabenz (GBZ, GA, Wytensin, Wy-8678,BR-750) is an orally active central alpha 2-adrenoceptor (α2 adrenergic receptor) agonist with antihypertensive action.
Interleukin-6 (IL6), colony stimulating factor 2 (Csf2), and cyclooxygenase-2 (Cox2) are downregulated by guanabenz-driven phosphorylation of eukaryotic translation initiation factor 2α (eIF2α). Although expression of IL1β and Tumor Necrosis Factor-α (TNFα) was suppressed by guanabenz, their downregulation was not directly mediated by eIF2α signaling.[2]
[1] B Holmes, et al. Drugs. 1983 Sep;26(3):212-29. [2] Takigawa S, et al. Int J Mol Sci. 2016 May 5;17(5):674.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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