HIF-2α-IN-4 |
| Catalog No.GC63678 |
HIF-2α-IN-4 es un potente inhibidor del factor inducible por hipoxia-2α (HIF-2α) traducciÓn, con un IC50 de 5 μM. HIF-2α-IN-4 disminuye tanto el HIF-2&8#945 constitutivo como el inducido por hipoxia; expresiÓn de proteÍnas. HIF-2α-IN-4 vincula su elemento sensible al hierro 5'UTR a la detecciÓn de oxÍgeno.
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Cas No.: 882268-69-1
Sample solution is provided at 25 µL, 10mM.
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HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5’UTR iron-responsive element to oxygen sensing[1].
HIF-2α-IN-4 (compound 76) (10 μM; 786-O cells) decreases HIF-2α mRNA translation in an mTOR-independent manner[1].HIF-2α-IN-4 decreases HIF-2α protein and HIF-2α target gene expression in normoxia and hypoxia[1].
[1]. Zimmer M, et al. Small-molecule inhibitors of HIF-2α translation link its 5’UTR iron-responsive element to oxygen sensing. Mol Cell. 2008;32(6):838-848.
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