HIF-2α-IN-4 |
| Catalog No.GC63678 |
HIF-2α-IN-4는 저산소증 유도 인자-2α의 강력한 억제제입니다. (HIF-2α) 번역, IC50 5 μM. HIF-2α-IN-4는 구성 및 저산소증 유발 HIF-2α를 모두 감소시킵니다. 단백질 발현. HIF-2α-IN-4는 5'UTR 철 반응성 요소를 산소 감지에 연결합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 882268-69-1
Sample solution is provided at 25 µL, 10mM.
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HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5’UTR iron-responsive element to oxygen sensing[1].
HIF-2α-IN-4 (compound 76) (10 μM; 786-O cells) decreases HIF-2α mRNA translation in an mTOR-independent manner[1].HIF-2α-IN-4 decreases HIF-2α protein and HIF-2α target gene expression in normoxia and hypoxia[1].
[1]. Zimmer M, et al. Small-molecule inhibitors of HIF-2α translation link its 5’UTR iron-responsive element to oxygen sensing. Mol Cell. 2008;32(6):838-848.
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