IRE1α kinase-IN-2 |
| Catalog No.GC64232 |
IRE1α quinasa-IN-2 es un potente IRE1α inhibidor de quinasa, con un EC50 de 0,82 μM. IRE1α la quinasa-IN-2 inhibe IRE1α autofosforilaciÓn de cinasa (IC50 = 3,12 μ M). IRE1α quinasa-IN-2 inhibe el empalme del ARNm de XBP1 en las lÍneas celulares WT.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1414938-21-8
Sample solution is provided at 25 µL, 10mM.
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IRE1α kinase-IN-2 is a potent IRE1α kinase inhibitor, with an EC50 of 0.82 μM. IRE1α kinase-IN-2 inhibits IRE1α kinase autophosphorylation (IC50=3.12 μM). IRE1α kinase-IN-2 inhibits XBP1 mRNA splicing in the WT cell lines[1].
IRE1α kinase-IN-2 (compound 3) inhibits XBP1 mRNA splicing, even during ER stress[1].
[1]. Wang L, Perera BG, Hari SB, et al. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012;8(12):982-989.
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