JND3229 |
| Catalog No.GC65436 |
JND3229 es un inhibidor reversible de EGFRC797S con valores IC50 de 5,8, 6,8 y 30,5 nM para EGFRL858R/T790M/C797S, EGFRWT y EGFRL858R/T790M, respectivamente. JND3229 tiene una buena actividad antiproliferativa y puede inhibir eficazmente el crecimiento tumoral in vivo. JND3229 se puede utilizar en la investigaciÓn del cÁncer, especialmente en el carcinoma de células no pequeÑas.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2260886-64-2
Sample solution is provided at 25 µL, 10mM.
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JND3229 is a highly potent and fourth-generation EGFRC797S reversible inhibitor with IC50 value of 5.8 nM, and also potently suppressed EGFRL858R/T790M and EGFRWT with IC50 values of 30.5 and 6.8 nM.
[1]. Lu X, et al. Discovery of JND3229 as a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy. ACS Med Chem Lett. 2018 Oct 8;9(11):1123-1127.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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