K-Ras ligand-Linker Conjugate 4 |
Catalog No.GC39226 |
El conjugado 4 ligando-enlazador de K-Ras incorpora un ligando para la fracciÓn reclutadora de K-Ras y un enlazador PROTAC, que recluta ligasas E3 (como VHL, CRBN, MDM2 e IAP). El ligando K-Ras-enlazador conjugado 4 se puede utilizar en la sÍntesis de PROTAC K-Ras Degrader-1, que es un potente degradador PROTAC K-Ras que presenta una eficacia de degradaciÓn ≥70 % en células SW1573.
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Cas No.: 2378261-83-5
Sample solution is provided at 25 µL, 10mM.
K-Ras ligand-Linker Conjugate 4 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 4 can be used in the synthesis of PROTAC K-Ras Degrader-1 , which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
[1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.
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