KAS 08 |
| Catalog No.GC52291 |
A STING activator
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 203861-20-5
Sample solution is provided at 25 µL, 10mM.
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KAS 08 is an activator of stimulator of interferon genes (STING).1 It activates STING with an EC50 value of 0.33 µM in a reporter assay using THP-1 human monocytes. KAS 08 increases the levels of IFN-β and IP-10 in the presence, but not absence, of cGAMP. It reduces the viability of CT26 mouse colorectal cancer cells when used at concentrations ranging from 0.31 to 20 µM. KAS 08 (15 mg/kg), when administered in combination with exogenous 2'3'-cGAMP , reduces tumor growth in a CT26 mouse syngeneic model.
1.Jung, H.R., Jo, S., Jeon, M.J., et al.Development of small-molecule STING activators for cancer immunotherapyBiomedicines10(1)33(2022)
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