KDU691 |
| Catalog No.GC32118 |
KDU691, una imidazopirazina con potente actividad antiparasitaria contra esquizontes en estadio sanguÍneo, gametocitos y estadios hepÁticos, es un inhibidor de Plasmodium PI4K.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1513879-19-0
Sample solution is provided at 25 µL, 10mM.
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KDU691 is a PI4K inhibitor.
During the 5 days of dosing, no major weight changes are observed in the animals that receive KDU691 as prophylactic treatment (group 691-proph). From the fourth day of dosing, the animals that are treated with KDU691 show a transient yellow skin color. The KDU691 radical-cure group (group 691-RC) becomes blood-stage positive again at 31.8±0.5 days p.i. (range, 31 to 32 days). Clinical chemistry analysis of the group 691-RC monkeys reveals that bilirubin levels accumulate during the 5-day radical-cure treatment with KDU691[1].
[1]. Zeeman AM, et al. PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2858-63.
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