LDHA-IN-3 |
| Catalog No.GC63795 |
LDHA-IN-3, como compuesto de selenobenceno, es un potente inhibidor no competitivo de la lactato deshidrogenasa (LDHA) (IC50 = 145,2 nM). LDHA-IN-3 se puede utilizar para la investigaciÓn del cÁncer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 227010-33-5
Sample solution is provided at 25 µL, 10mM.
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LDHA-IN-3, as a selenobenzene compound, is a potent, noncompetitive lactate dehydrogenase (LDHA) inhibitor (IC50=145.2 nM). LDHA-IN-3 can be used for the research of cancer[1].
PSTMB (0~500 μM; 48 hours; MCF-7 cells) shows cytotoxic effect[1].PSTMB (0.01~1 μM) shows dose-dependent inhibition of LDHA activity. PSTMB (0~0.5 μM) inhibits LDHA activity in Michaelis-Menten and Lineweaver-Burk plots. PSTMB (30 and 50 μM; HT29 cells) induces ROS production and mitochondrial damage[1].PSTMB can bind to LDHA protein efficiently. PSTMB induces the intrinsic pathway-mediated apoptosis of cancer cells via production of mitochondrial ROS[1].
[1]. Kim EY, et al. A Novel Lactate Dehydrogenase Inhibitor, 1-(Phenylseleno)-4-(Trifluoromethyl) Benzene, Suppresses Tumor Growth through Apoptotic Cell Death. Sci Rep. 2019;9(1):3969. Published 2019 Mar 8.
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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