m-PEG10-acid |
| Catalog No.GC67238 |
m-PEG10-acid es un conector ADC de PEG de 10 unidades no escindible que se utiliza en la síntesis de conjugados de anticuerpo-fármaco (ADC). m-PEG10-acid también es un conector PROTAC basado en PEG que se puede usar en la síntesis de PROTAC.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2409969-94-2
Sample solution is provided at 25 µL, 10mM.
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m-PEG10-acid is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG10-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
[1]. John F. Donovan et al. Pegylated prodrugs of phenolic trpv1 agonists. WO2020023794A1.
[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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