m-PEG10-acid |
| Catalog No.GC67238 |
m-PEG10-산은 항체-약물 접합체(ADC)의 합성에 사용되는 절단 불가능한 10단위 PEG ADC 링커입니다. 821d96072c2d58d8970e76f526b0f6b8m-PEG10-산은 또한 PROTAC 합성에 사용될 수 있는 PEG 기반 PROTAC 링커입니다.821d96072c2d58d8970e76f526b0f6b8
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2409969-94-2
Sample solution is provided at 25 µL, 10mM.
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m-PEG10-acid is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG10-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
[1]. John F. Donovan et al. Pegylated prodrugs of phenolic trpv1 agonists. WO2020023794A1.
[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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