Methacholine bromide (Synonyms: Acetyl-β-methylcholine bromide) |
| Catalog No.GC67620 |
El bromuro de metacolina (acetil-β-metilcolina) es un potente agonista muscarínico-3 (M3). El bromuro de metacolina actúa directamente sobre los receptores de acetilcolina en el músculo liso causando broncoconstricción y estrechamiento de las vías respiratorias. El bromuro de metacolina muestra una alta sensibilidad para identificar la hiperreactividad bronquial (BHR). El bromuro de metacolina se puede utilizar para medir la hiperreactividad de las vías respiratorias (AHR) como ayuda diagnóstica en la evaluación de personas con síntomas parecidos al asma y tasas normales de flujo espiratorio en reposo.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 333-31-3
Sample solution is provided at 25 µL, 10mM.
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Methacholine (Acetyl-β-methylcholine) bromide is a potent muscarinic-3 (M3) agonist. Methacholine bromide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine bromide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine bromide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates[1][2][3][4].
Methacholine bromide (0.5 µg/kg plus 5 µg/kg/min for 30 min) induces bronchoconstriction in dogs[4].
Methacholine bromide (0.5 mg/kg; i.v.) induces bronchoconstriction was inhibited by bradykinin (4-40 µg/kg; i.v.) in a a dose-dependent manner in mouse[5].
| Animal Model: | 9-week female BALB/c mice[6] |
| Dosage: | 0.03, 0.1, 0.3, 1 mg/kg |
| Administration: | I.v |
| Result: | Induced severe bronchoconstriction. |
[1]. Cohen J, et al. Relationship between airway responsiveness to neurokinin A and methacholine in asthma. Pulm Pharmacol Ther. 2005;18(3):171-176.
[2]. Anderson SD, et al. Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma. Respir Res. 2009;10(1):4. Published 2009 Jan 23.
[3]. Cockcroft DW. Methacholine challenge methods. Chest. 2008;134(4):678-680.
[4]. Kabara S, et al. Differential effects of thiopental on methacholine- and serotonin-induced bronchoconstriction in dogs. Br J Anaesth. 2003 Sep;91(3):379-84.
[5]. Folkerts G, et al. Bradykinin causes inhibition of methacholine-induced bronchoconstriction in vivo in mice. Naunyn Schmiedebergs Arch Pharmacol. 2001 Jul;364(1):53-8.
[6]. Vitorasso RL, et al. Methacholine dose response curve and acceptability criteria of respiratory mechanics modeling. Exp Lung Res. 2020 Feb-Mar;46(1-2):23-31.
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