Methacholine bromide (Synonyms: Acetyl-β-methylcholine bromide) |
| Catalog No.GC67620 |
Le bromure de méthacholine (acétyl-β-méthylcholine) est un puissant agoniste muscarinique-3 (M3). Le bromure de méthacholine agit directement sur les récepteurs de l'acétylcholine sur les muscles lisses, provoquant une bronchoconstriction et un rétrécissement des voies respiratoires. Le bromure de méthacholine montre une grande sensibilité pour identifier l'hyperréactivité bronchique (HRB). Le bromure de méthacholine peut être utilisé pour mesurer l'hyperréactivité des voies respiratoires (AHR) en tant qu'aide au diagnostic dans l'évaluation des personnes présentant des symptômes de type asthmatique et des débits expiratoires au repos normaux.
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Cas No.: 333-31-3
Sample solution is provided at 25 µL, 10mM.
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Methacholine (Acetyl-β-methylcholine) bromide is a potent muscarinic-3 (M3) agonist. Methacholine bromide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine bromide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine bromide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates[1][2][3][4].
Methacholine bromide (0.5 µg/kg plus 5 µg/kg/min for 30 min) induces bronchoconstriction in dogs[4].
Methacholine bromide (0.5 mg/kg; i.v.) induces bronchoconstriction was inhibited by bradykinin (4-40 µg/kg; i.v.) in a a dose-dependent manner in mouse[5].
| Animal Model: | 9-week female BALB/c mice[6] |
| Dosage: | 0.03, 0.1, 0.3, 1 mg/kg |
| Administration: | I.v |
| Result: | Induced severe bronchoconstriction. |
[1]. Cohen J, et al. Relationship between airway responsiveness to neurokinin A and methacholine in asthma. Pulm Pharmacol Ther. 2005;18(3):171-176.
[2]. Anderson SD, et al. Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma. Respir Res. 2009;10(1):4. Published 2009 Jan 23.
[3]. Cockcroft DW. Methacholine challenge methods. Chest. 2008;134(4):678-680.
[4]. Kabara S, et al. Differential effects of thiopental on methacholine- and serotonin-induced bronchoconstriction in dogs. Br J Anaesth. 2003 Sep;91(3):379-84.
[5]. Folkerts G, et al. Bradykinin causes inhibition of methacholine-induced bronchoconstriction in vivo in mice. Naunyn Schmiedebergs Arch Pharmacol. 2001 Jul;364(1):53-8.
[6]. Vitorasso RL, et al. Methacholine dose response curve and acceptability criteria of respiratory mechanics modeling. Exp Lung Res. 2020 Feb-Mar;46(1-2):23-31.
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