Mutant IDH1-IN-2 |
| Catalog No.GC32966 |
El mutante IDH1-IN-2 es un inhibidor de las proteÍnas mutantes de isocitrato deshidrogenasa (IDH), con IC50 de LS-MS en el ensayo bioquÍmico, IC50 de 16,6 nM en el ensayo bioquÍmico de fluorescencia.
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Cas No.: 1429176-69-1
Sample solution is provided at 25 µL, 10mM.
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Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay.Target: Mutant IDH1Mutant IDH1-IN-2 has a neomorphic activity and in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer. More bioactivity information in Patent WO 2013046136A1 (Example 224).
[1]. Huangshu, et al. 3-Pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH and their preparation
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