NRX-252262 |
| Catalog No.GC65336 |
NRX-252262 es un potente potenciador de la interacciÓn entre β-catenina y su ligasa E3 afÍn, SCFβ-TrCP, induce la degradaciÓn de β-catenina mutante, con una CE50 de 3,8 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2438637-61-5
Sample solution is provided at 25 µL, 10mM.
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NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM[1].
NRX-252262 (35 μM) causes S33E/S37A mutant β-catenin degradation in cells[1].
[1]. Kyle R. Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications. 2019 March.
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