NSC5844 (RE-640) |
| Catalog No.GC33969 |
NSC5844 (RE-640) (RE-640) es un derivado de la 4-aminoquinolina, con actividad antitumoral y antipalÚdica.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 140926-75-6
Sample solution is provided at 25 µL, 10mM.
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NSC5844 is a 4-aminoquinoline derivative, with antitumor and antimalarial activity.
NSC5844 (Compound 10) is a 4-aminoquinoline derivative, and has antitumor activity with GI50s of 7.35 ± 0.10 μM and 14.80 ± 0.35 μM against MDA-MB-468 and MCF-7 cells, respectively[1]. NSC5844 (Compound 1) is cytotoxic to P. falciparum, inhibits the growth of chloroquine-sensitive (D-6) and -resistant (W-2) clones of P. falciparum, with IC50s of 17 and 27 nM, respectively[2].
[1]. Zhang H, et al. Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives. Biomed Pharmacother. 2008 Feb;62(2):65-9. Epub 2007 May 24. [2]. Vennerstrom JL, et al. Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria. J Med Chem. 1992 May 29;35(11):2129-34.
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