Palbociclib-propargyl (Synonyms: PROTAC CDK6 ligand 1) |
| Catalog No.GC61395 |
Palbociclib-propargyl es un ligando para la proteÍna objetivo CDK6 para PROTAC y se une al ligando CRBN a través de un conector PEG para hacer un PROTAC CP-10. CP-10 muestra un DC50 de 2,1 nM para CDK6.
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Cas No.: 2366269-23-8
Sample solution is provided at 25 µL, 10mM.
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Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6[1].
[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582.
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