Palbociclib-propargyl (Synonyms: PROTAC CDK6 ligand 1) |
| Catalog No.GC61395 |
팔보시클립-프로파길은 PROTAC에 대한 표적 단백질 CDK6의 리간드이며, PEG 링커를 통해 CRBN 리간드에 결합하여 PROTAC CP-10을 만듭니다. CP-10은 CDK6에 대해 2.1nM의 DC50을 보여줍니다.
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Cas No.: 2366269-23-8
Sample solution is provided at 25 µL, 10mM.
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Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6[1].
[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582.
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