PD 90780 |
| Catalog No.GC34703 |
PD 90780 es un antagonista no peptÍdico del factor de crecimiento nervioso (NGF).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 77422-99-2
Sample solution is provided at 25 µL, 10mM.
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PD 90780 is a non peptide antagonist of nerve growth factor (NGF) binding to the P75 NGF receptor, inhibits NGF-p75 NTR interaction with IC50s values of 23.1 µM and 1.8 µM in PC12 cells and PC12 nnr5 cells, respectively [1] . IC50: 23.1 µM (NGF, PC12 cells), 1.8 µM (NGF, PC12 nnr5 cells)
[1]. Colquhoun A , et al. Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J Pharmacol Exp Ther. 2004 Aug;310(2):505-11.
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