Peptide YY (3-36) (trifluoroacetate salt) (Synonyms: Pancreatic Peptide YY, Peptide Tyrosine Tyrosine) |
Catalog No.GC52502 |
A satiety hormone
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Peptide YY (PYY) is a polypeptide that is released postprandially in proportion to meal energy content by endocrine L cells in the ileum and colon in order to regulate appetite.1 PYY, along with neuropeptide Y , inhibits gastrointestinal motility and electrolyte secretion, which is thought to indicate satiety through a potent feedback signal on hypothalamic circuits.1,2 Upon release, PYY is cleaved to PYY (3-36), which is a preferred agonist at presynaptic inhibitory type 2 NPY autoreceptors (EC50 = 11.4 nM in human colon mucosa).3 PYY (3-36) has been associated with dose-dependent weight loss in various obesity models including ob/ob mice, diet-induced obese mice, and non-diabetic fatty Zucker rats.2
1.Holzer, P., Reichmann, F., and Farzi, A.Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axisNeuropeptides46(6)261-274(2012) 2.le Roux, C.W., and Bloom, S.R.Peptide YY, appetite and food intakeProc. Nutr. Soc.64(2)213-216(2005) 3.Cox, H.M., and Tough, I.R.Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosaBr. J. Pharmacol.135(6)1505-1512(2002)
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