Propargyl-PEG2-acid |
| Catalog No.GC61551 |
Propargyl-PEG2-acid es un conector ADC de PEG de 2 unidades no escindible que se utiliza en la sÍntesis de conjugados de anticuerpo-fÁrmaco (ADC). Propargyl-PEG2-acid también es un conector PROTAC basado en PEG que se puede usar en la sÍntesis de PROTAC.
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Cas No.: 1859379-85-3
Sample solution is provided at 25 µL, 10mM.
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Propargyl-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. Sano K, et al. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6.
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