QWF |
| Catalog No.GC50531 |
MRGPRX2 antagonist; also NK1 receptor antagonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 126088-82-2
Sample solution is provided at 25 µL, 10mM.
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Tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.
Hagiwara et al (1992) Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists. J.Med.Chem. 35 2015 PMID:1375965 |Azimi et al (2016) Dual action of neurokinin-1 antagonists on Mas-related GPCRs. JCI Insight. 1 e89362 PMID:27734033
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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