(Rac)-CFT7455 (Synonyms: (Rac)-CFT7455) |
| Catalog No.GC65477 |
(Rac)-CFT7455 es un factor de transcripciÓn con dedos de zinc que degrada Ikaros (IKZF1) y Aiolos (IKZF3), que actÚa a través de la vÍa del proteasoma de la ubiquitina, con un GI50 de 0,05 nM para las células NCIH929.1. (Rac)-CFT7455 es el isÓmero racémico de CFT7455, que es un degradador IKZF1/IKZF3 con actividad anticancerÍgena.
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Cas No.: 2504233-68-3
Sample solution is provided at 25 µL, 10mM.
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(Rac)-CFT7455 is a zinc finger transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) degrader, acting via the ubiquitin proteasome pathway, with a GI50 of 0.05 nM for NCIH929.1 cells. (Rac)-CFT7455 is the racemic isomer of CFT7455 which is a IKZF1/IKZF3 degrader with anticancer activity[1][2].
[1]. David Proia et al. Advantageous therapies for disorders mediated by ikaros or aiolos. WO2022032132A1 (compound 5)
[2]. James A. Henderson, et al. Abstract LB007: CFT7455: A novel, IKZF1/3 degrader that demonstrates potent tumor regression in IMiD-resistant multiple myeloma (MM) xenograft models. Cancer Res (2021) 81 (13_Supplement): LB007.
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