(Rac)-CFT7455 (Synonyms: (Rac)-CFT7455) |
| Catalog No.GC65477 |
(Rac)-CFT7455는 NCIH929.1 세포에 대해 GI50이 0.05nM인 유비퀴틴 프로테아좀 경로를 통해 작용하는 아연 핑거 전사 인자 Ikaros(IKZF1) 및 Aiolos(IKZF3) 분해자입니다. (Rac)-CFT7455는 항암 활성을 갖는 IKZF1/IKZF3 분해제인 CFT7455의 라세미 이성질체이다.
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Cas No.: 2504233-68-3
Sample solution is provided at 25 µL, 10mM.
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(Rac)-CFT7455 is a zinc finger transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) degrader, acting via the ubiquitin proteasome pathway, with a GI50 of 0.05 nM for NCIH929.1 cells. (Rac)-CFT7455 is the racemic isomer of CFT7455 which is a IKZF1/IKZF3 degrader with anticancer activity[1][2].
[1]. David Proia et al. Advantageous therapies for disorders mediated by ikaros or aiolos. WO2022032132A1 (compound 5)
[2]. James A. Henderson, et al. Abstract LB007: CFT7455: A novel, IKZF1/3 degrader that demonstrates potent tumor regression in IMiD-resistant multiple myeloma (MM) xenograft models. Cancer Res (2021) 81 (13_Supplement): LB007.
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