1-Deoxynojirimycin (hydrochloride) (Synonyms: 1-DNJ, 1-dNM, Moranoline) |
| Catalog No.GC41992 |
La 1-desoxinojirimicina (clorhidrato) (clorhidrato de Duvoglustat) es un inhibidor potente y activo por vía oral de la α-glucosidasa.
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Cas No.: 73285-50-4
Sample solution is provided at 25 µL, 10mM.
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1-Deoxynojirimycin (1-dNM) (hydrochloride), produced by Bacillus species, is a glucose analog that potently inhibits α-glucosidase I and II. It prevents the formation of complex N-linked oligosaccharides in yeast and intact mammalian cells by inhibiting both α-glucosidase I and II with IC50 values of ~2 µM. The FDA has granted orphan drug designation to dNM (hydrochloride) for the treatment of Pompe disease, an inherited lysosomal storage disorder caused by a mutation that alters the structure and stability of α-glucosidase. 1-dNM, at a concentration of 0.4 mM, also inhibits virus spread in HIV-infected lymphocyte cultures by interfering with α-glucosidase activity.
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