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Ro 67-7476

Catalog No.GC12485

Ro 67-7476 es un potente modulador alostérico positivo de mGluR1 y potencia la liberaciÓn de calcio inducida por glutamato en células HEK293 que expresan mGluR1a de rata con una EC50 de 60,1 nM. Ro 67-7476 es un potente agonista de P-ERK1/2y activa la fosforilaciÓn de ERK1/2 en ausencia de glutamato aÑadido exÓgenamente (CE50 = 163,3 nM).

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Ro 67-7476 Chemical Structure

Cas No.: 298690-60-5

Tamaño Precio Disponibilidad Cantidad
10mM (in 1mL DMSO)
79,00 $
Disponible
2mg
45,00 $
Disponible
5mg
90,00 $
Disponible
10mg
144,00 $
Disponible
25mg
297,00 $
Disponible
50mg
540,00 $
Disponible
100mg
900,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. Displays no activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.target: mGlu1 EC 50: 60.1 nM(1) Ro 67-7476 (10 μM) can directly block the GIRK channel (to 67 ± 2% of control). (2) Ro 67-7476 enhance the glutamate-induced current in all chimeric receptors containing the transmembrane (TM) region of rmGlu1a (R1, R1-R5N, R1-R5C, and R5-R1TM) but not in those containing the TM region of rmGlu5a (R5, R5-R1N, R5-R1C, and R1-R5TM.(3) The application of Ro 67-7476 (3 μM) produced no effect alone but resulted in a marked potentiation of the mGlu1 EPSC amplitude.

References:
[1]. Hemstapat K et al. A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol Pharmacol. 2006 Aug, 70(2), 616-26
[2]. Knoflach F et al. Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13402-7.

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