(S,R,S)-AHPC-O-Ph-PEG1-NH2 (Synonyms: VH032-O-Ph-PEG1-NH2) |
| Catalog No.GC62183 |
(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) es un conjugado ligando-enlazador E3 e incorpora un ligando VHL para la ubiquitina ligasa E3 y un conector PROTAC . (S,R,S)-AHPC-O-Ph-PEG1-NH2 se utiliza en el degradador-1 PROTAC EED. PROTAC EED degradador-1 es un EED dirigido a PROTAC con un pKD de 9,02.
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Cas No.: 2361117-24-8
Sample solution is provided at 25 µL, 10mM.
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(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) is E3 ligase ligand-linker conjugate and incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-O-Ph-PEG1-NH2 is used in PROTAC EED degrader-1 . PROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02[1].
[1]. Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9.
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