SB-633825 |
| Catalog No.GC60335 |
SB-633825 es un inhibidor potente y competitivo con ATP de TIE2, LOK (STK10) y BRK con IC50 de 3,5 nM, 66 nM, 150 nM, respectivamente.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 956613-01-7
Sample solution is provided at 25 µL, 10mM.
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SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis[1].
SB-633825 inhibits TIE2 Tyrosine-protein kinase (TIE2), lymphocyte-oriented kinase (LOK; STK10) and breast tumor kinase (Brk; PTK6)[1]. SB-633825 inhibits LOK to 44% maximal activity and TIE2 to 75% maximal activity at 0.1 µM[1].
[1]. Elkins JM, et al. Comprehensive characterization of the Published Kinase Inhibitor Set. Nat Biotechnol. 2016 Jan;34(1):95-103.
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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