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SCH 336 (Synonyms: SCH-225336)

Catalog No.GC50271

SCH 336 es un agonista CB2 potente, selectivo, inverso y activo por vÍa oral.

Products are for research use only. Not for human use. We do not sell to patients.

SCH 336 Chemical Structure

Cas No.: 447459-51-0

Tamaño Precio Disponibilidad Cantidad
10 mg
241,00 $
Disponible
50 mg
915,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Highly potent and selective CB2 receptor inverse agonist (Ki = 1.8 nM, EC50 = 2 nM). Displays 100-fold selectivity for CB2 receptors over CB1. Increases forskolin stimulated cAMP accumulation in CHO cells expressing human CB2 receptors. Inhibits leukocyte migration in a murine model of delayed-type hypersensitivity and inhibits antigen-induced lung eosinophilia in a mouse allergy model.

Lunn et al (2006) A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo. J.Pharmacol.Exp.Ther. 316 780 PMID:16258021

Chemical Properties

Cas No. 447459-51-0 SDF
Sinónimos SCH-225336
Canonical SMILES CS(N[C@@H](C)C1=CC=C(S(C2=C(S(=O)(C3=CC=C(OC)C=C3)=O)C=C(OC)C=C2)(=O)=O)C=C1)(=O)=O
Formula C23H25NO8S3 M.Wt 539.64
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.8531 mL 9.2654 mL 18.5309 mL
5 mM 0.3706 mL 1.8531 mL 3.7062 mL
10 mM 0.1853 mL 0.9265 mL 1.8531 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for SCH 336

Average Rating: 5 ★★★★★ (Based on Reviews and 39 reference(s) in Google Scholar.)

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