SCH 336 (Synonyms: SCH-225336) |
| Catalog No.GC50271 |
SCH 336 est un agoniste CB2 puissant, sélectif, inverse et actif par voie orale.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 447459-51-0
Sample solution is provided at 25 µL, 10mM.
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Highly potent and selective CB2 receptor inverse agonist (Ki = 1.8 nM, EC50 = 2 nM). Displays 100-fold selectivity for CB2 receptors over CB1. Increases forskolin stimulated cAMP accumulation in CHO cells expressing human CB2 receptors. Inhibits leukocyte migration in a murine model of delayed-type hypersensitivity and inhibits antigen-induced lung eosinophilia in a mouse allergy model.
Lunn et al (2006) A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo. J.Pharmacol.Exp.Ther. 316 780 PMID:16258021
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