Sclareolide (Synonyms: Norambreinolide, (+)-Sclareolide, (R)-(+)-Sclareolide)

Target: NpABC1

IC50: NA

Sclareolide (Norambreinolide) is a sesquiterpene lactone natural product derived from various plant sources including Salvia yosgadensis, Salvia sclarea, and cigar tobacco [1]. Sclareolide is a close analog of sclareol, an antifungal diterpene produced at the leaf surface of Nicotiana spp. Moreover, Sclareolide is used as a fragrance in cosmetics and has been more recently marketed as a weight loss supplement.

In vitro: Sclareolide (20, 100, and 500 μM) dose-dependently induced NpABC1 expression of a plasma membrane protein in Nicotiana plumbaginifolia cells [1]. Sclareolide (20 μM) had no effect on Nicotiana plumbaginifolia cell growth although the induction of NpABC1 expression. In addition, NpABC1 transcript levels were high 3 hr after sclareolide addition and then decreased. However, the level of NpABC1 protein expression remained fairly stable for up to 12 hr [1]. The 160-kD NpABC1 protein is localized in the plasma membrane and is involved in the secretion of a secondary metabolite which plays an important role in plant defense [1].

In vivo: N/A

Reference:
1.  Jasinski M, Stukkens Y, Degand H, Purnelle B, Marchand-Brynaert J, Boutry M. A plant plasma membrane ATP binding cassette-type transporter is involved in antifungal terpenoid secretion. Plant Cell. 2001;13(5):1095-107.