Sclareolide (Synonyms: Norambreinolide, (+)-Sclareolide, (R)-(+)-Sclareolide) |
Catalog No.GC11723
One-Click Copy Product Info
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Sesquiterpene lactone natural product
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 564-20-5
Sample solution is provided at 25 µL, 10mM.
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Target: NpABC1
IC50: NA
Sclareolide (Norambreinolide) is a sesquiterpene lactone natural product derived from various plant sources including Salvia yosgadensis, Salvia sclarea, and cigar tobacco [1]. Sclareolide is a close analog of sclareol, an antifungal diterpene produced at the leaf surface of Nicotiana spp. Moreover, Sclareolide is used as a fragrance in cosmetics and has been more recently marketed as a weight loss supplement.
In vitro: Sclareolide (20, 100, and 500 μM) dose-dependently induced NpABC1 expression of a plasma membrane protein in Nicotiana plumbaginifolia cells [1]. Sclareolide (20 μM) had no effect on Nicotiana plumbaginifolia cell growth although the induction of NpABC1 expression. In addition, NpABC1 transcript levels were high 3 hr after sclareolide addition and then decreased. However, the level of NpABC1 protein expression remained fairly stable for up to 12 hr [1]. The 160-kD NpABC1 protein is localized in the plasma membrane and is involved in the secretion of a secondary metabolite which plays an important role in plant defense [1].
In vivo: N/A
Reference:
1. Jasinski M, Stukkens Y, Degand H, Purnelle B, Marchand-Brynaert J, Boutry M. A plant plasma membrane ATP binding cassette-type transporter is involved in antifungal terpenoid secretion. Plant Cell. 2001;13(5):1095-107.
| Cas No. | 564-20-5 | SDF | |
| Synonyms | Norambreinolide, (+)-Sclareolide, (R)-(+)-Sclareolide | ||
| Chemical Name | (3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyldecahydronaphtho[2,1-b]furan-2(3aH)-one | ||
| Canonical SMILES | CC(CCC[C@@]1([C@@]2([H])CC(O3)=O)C)([C@]1([H])CC[C@]23C)C | ||
| Formula | C16H26O2 | M.Wt | 250.38 |
| Solubility | DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml,DMSO: 15 mg/ml,Ethanol: 10 mg/ml | Storage | 4°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.9939 mL | 19.9696 mL | 39.9393 mL |
| 5 mM | 798.8 μL | 3.9939 mL | 7.9879 mL |
| 10 mM | 399.4 μL | 1.997 mL | 3.9939 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)