SIAIS178 |
| Catalog No.GC39262 |
SIAIS178 es un degradador BCR-ABL potente y selectivo basado en tecnologÍa PROTAC con un IC50 de 24 nM. SIAIS178 provoca la degradaciÓn eficaz de la proteÍna BCR-ABL al reclutar la ubiquitina ligasa E3 de Von Hippel-Lindau (VHL). SIAIS178 tiene actividad anticancerÍgena.
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Cas No.: 2376047-73-1
Sample solution is provided at 25 µL, 10mM.
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SIAIS178 is a potent and selective BCR-ABL degrader based on PROTAC technology with an IC50 of 24 nM. SIAIS178 causes effective degradation of BCR-ABL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. SIAIS178 has anticancer activity[1].
[1]. Zhao Q, et al. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J Med Chem. 2019 Oct 24;62(20):9281-9298.
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