SLM6031434 (hydrochloride) |
| Catalog No.GC46222 |
SLM6031434 (clorhidrato) es un inhibidor altamente selectivo de la esfingosina quinasa 2 (SphK2) con Kis de 0,4 μM, 0,5 μM, \u003e20 μM, 22 μM para mSphK2, rSphK2, mSphK1 y rSphK1, respectivamente.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1897379-34-8
Sample solution is provided at 25 µL, 10mM.
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SLM6031434 is an inhibitor of sphingosine kinase 2 (SPHK2) (Ki = 0.4 μM for the recombinant mouse enzyme).1 It is selective for SPHK2 over SPHK1 (Kis = >20 μM). It decreases sphingosine-1-phosphate and increases sphingosine levels in U937 monocytic leukemia cells in a concentration-dependent manner. SLM6031434 (5 mg/kg) reduces blood S1P levels in Sphk1-/-, but not Sphk2-/-, mice. SLM6031434 also increases blood S1P levels in wild-type mice and rats.
|1. Kharel, Y., Morris, E.A., Congdon, M.D., et al. Sphingosine kinase 2 inhibition and blood sphingosine 1-phosphate levels. J. Pharmacol. Exp. Ther. 355(1), 23-31 (2015).
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