SLM6031434 (hydrochloride) |
| Katalog-Nr.GC46222 |
SLM6031434 (Hydrochlorid) ist ein hochselektiver Sphingosinkinase 2 (SphK2)-Inhibitor mit Kis von 0,4 μM, 0,5 μM, \u003e20 μM, 22 μM für mSphK2, rSphK2, mSphK1 bzw. rSphK1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1897379-34-8
Sample solution is provided at 25 µL, 10mM.
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SLM6031434 is an inhibitor of sphingosine kinase 2 (SPHK2) (Ki = 0.4 μM for the recombinant mouse enzyme).1 It is selective for SPHK2 over SPHK1 (Kis = >20 μM). It decreases sphingosine-1-phosphate and increases sphingosine levels in U937 monocytic leukemia cells in a concentration-dependent manner. SLM6031434 (5 mg/kg) reduces blood S1P levels in Sphk1-/-, but not Sphk2-/-, mice. SLM6031434 also increases blood S1P levels in wild-type mice and rats.
|1. Kharel, Y., Morris, E.A., Congdon, M.D., et al. Sphingosine kinase 2 inhibition and blood sphingosine 1-phosphate levels. J. Pharmacol. Exp. Ther. 355(1), 23-31 (2015).
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