Src Inhibitor 3 |
| Catalog No.GC61294 |
El Inhibidor 3 de Src es un potente inhibidor oralmente activo de la quinasa c-terminal de Src (CSK) con valores IC50 por debajo de 3 nM y 4 nM en los ensayos CSK HTRF y Caliper, respectivamente.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2380027-49-4
Sample solution is provided at 25 µL, 10mM.
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Src Inhibitor 3 is a potent, orally active c-terminal Src kinase (CSK) with IC50 values below 3 nM and 4 nM in CSK HTRF and Caliper assay, respectively. Src Inhibitor 3 shows the ability to increase T cell proliferation induced by T cell receptor signaling[1].
Src Inhibitor 3 reduces inhibitory LCK phosphorylation in vivo upon oral dosing and shows the ability to enhance T cell activation in response to antigen stimulation[1].
[1]. O'Malley DP, et al. Discovery of Pyridazinone and Pyrazolo[1,5-a]pyridine Inhibitors of C-Terminal Src Kinase. ACS Med Chem Lett. 2019 Sep 25;10(10):1486-1491.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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