Tannic acid |
| Catalog No.GC31686 |
El Ácido tÁnico es un nuevo bloqueador del canal hERG con IC50 de 3,4 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1401-55-4
Sample solution is provided at 25 µL, 10mM.
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Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM.
During the course of treatment, tannic acid significantly ameliorates these phenotypes in AD skin lesions. Tannic acid treatment aslo reduces these dermal changes compare with AD mice. Treatment with tannic acid increases PPARγ expression in AD skin sections. The PPARγ protein expression is suppressed in vehicle-treated AD mice, but when treats with tannic acid, its expression is increased dramatically. The IL-1β, TNFα, TNFR1, and COX2 protein expressions are significantly up-regulated in vehicle-treated AD mice, but significantly suppressed by tannic acid treatment[2].
[1]. Xi Chu, et al. Effects of Tannic Acid, Green Tea and Red Wine on hERG Channels Expressed in HEK293 Cells. PLoS One. 2015; 10(12): e0143797. [2]. Karuppagounder V, et al. Tannic acid modulates NFκB signaling pathway and skin inflammation in NC/Nga mice through PPARγ expression. Cytokine. 2015 Dec;76(2):206-13.
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