SLF TFA |
| Catalog No.GC61461 |
SLF TFA es un ligando sintético para la proteÍna de uniÓn a FK506 (FKBP) con una afinidad de 3,1 μM por FKBP51 y una IC50 de 2,6 μM por FKBP12. SLF TFA se puede utilizar en la sÍntesis de PROTAC.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2378802-47-0
Sample solution is provided at 25 µL, 10mM.
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SLF TFA is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF TFA can be used in the synthesis of PROTAC[1][2][3].
Three scout fragments-KB02, KB03, and KB05 are fused, which cover two different electrophile groups (chloroacetamide and acrylamide) and display broad cysteine reactivity in the human proteome-to the SLF ligand that binds tightly and selectively to FKBP12, a cytosolic prolyl isomerase that has been frequently used to study ligand-induced protein degradation[3].
[1]. Kolos JM, et al. FKBP Ligands-Where We Are and Where to Go• Front Pharmacol. 2018 Dec 5;9:1425. [2]. Wu X, et al. Creating diverse target-binding surfaces on FKBP12: synthesis and evaluation of a rapamycin analogue library. ACS Comb Sci. 2011 Sep 12;13(5):486-95. [3]. Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746.
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