Tapinarof (WBI 1001) |
Catalog No.GC31732 |
Tapinarof (WBI 1001) (WBI-1001) es un agonista natural del receptor de hidrocarburo de arilo (AhR) con una EC50 de 13 nM.
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Cas No.: 79338-84-4
Sample solution is provided at 25 µL, 10mM.
Tapinarof is a natural aryl hydrocarbon receptor (AhR) agonist with an EC50 of 13 nM.
Tapinarof activates the AhR pathway through direct binding. Tapinarof dose-dependently induces nuclear translocation of AhR in immortalized keratinocytes (HaCaT) (EC50=0.16 nM)[1].
Tapinarof acts through AhR to reduce inflammation in IMQ-treated mice. AhR-sufficient mice on a C57Bl/6 background exhibit a reduced clinical score after treatment with Tapinarof or 6-formylindolo(3,2-b)carbazole (FICZ). In contrast, AhR KO mice do not respond to the anti-inflammatory effects of Tapinarof. FICZ is used as a comparator in these studies and yields similar results, with dramatically reduced inflammatory responses in wild-type, but not AhR KO mice[1].
[1]. Smith SH, et al. Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans. J Invest Dermatol. 2017 Oct;137(10):2110-2119.
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