Tetrabenazine-d6 (Synonyms: TBZ-d6) |
| Catalog No.GC40180 |
La tetrabenazina D6 es la tetrabenazina marcada con deuterio, que es un inhibidor de VMAT utilizado para el tratamiento del trastorno del movimiento hipercinético.
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Cas No.: 1392826-25-3
Sample solution is provided at 25 µL, 10mM.
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Tetrabenazine-d6 is intended for use as an internal standard for the quantification of tetrabenazine by GC- or LC-MS. Tetrabenazine is an inhibitor of vesicular monoamine transporter 2 (VMAT2) that is selective over VMAT1 (Kis = 97 and >20,000 nM, respectively, in a serotonin uptake assay). It dose-dependently reduces levels of the monoamines norepinephrine , dopamine , and serotonin in rat brain and has been used to induce depressive-like behavior in animal models. Tetrabenazine (5 mg/kg) improves performance in balance beam and rotarod tests and prevents decreases in the number of striatal medium spiny neurons (MSNs) in a YAC128 transgenic mouse model of Huntington's disease. Formulations containing tetrabenazine have been used in the treatment of chorea associated with Huntington's disease.
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