TfR-T12 TFA |
| Catalog No.GC61502 |
TfR-T12 TFA es un péptido de uniÓn al receptor de transferrina (TfR) penetrado por BBB, que muestra una afinidad de uniÓn en el rango de nM.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range[1][2].
TfR-T12 binds to the TfR and is subsequently internalized into TfR-expressing cells[1].TfR-T12 is a synthetic peptide obtained by phage display, and is able to bind a different site on TfRs compared with transferrin. TfR-T12 can be chemically conjugated with a pegylated lipid derivative, 3-(N-succinimidyloxyglutaryl)aminopropyl- polyethyleneglycol(2000)- carbamyl distearoyl phosphatidylethanolamine (NHS-PEG2000-DSPE), and used as a functional material to construct the multifunctional lipid vesicles[2].
[1]. Carmen WÄngler, et al. In Vitro and Initial in Vivo Evaluation of (68)Ga-labeled Transferrin Receptor (TfR) Binding Peptides as Potential Carriers for Enhanced Drug Transport Into TfR Expressing Cells. Mol Imaging Biol. 2011 Apr;13(2):332-41. [2]. Li-Min Mu, et al. Lipid Vesicles Containing Transferrin Receptor Binding Peptide TfR-T 12 and Octa-Arginine Conjugate stearyl-R 8 Efficiently Treat Brain Glioma Along With Glioma Stem Cells. Sci Rep. 2017 Jun 14;7(1):3487.
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