UNC 926 hydrochloride |
| Catalog No.GC12419 |
An antagonist of L3MBTL1, L3MBTL3, and L3MBTL4
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1184136-10-4
Sample solution is provided at 25 µL, 10mM.
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UNC-926 is a methyl-lysine (Kme) reader domain inhibitor; inhibits L3MBTL1 with an IC50 of 3.9 μM.
UNC-926 inhibits L3MBTL1 with an IC50 of 3.9 μM. L3MBTL1UNC-926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3, with a decrease in affinity for the other MBT domains and no binding to CBX7. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1. It selectively inhibits the L3MBTL13xMBT-H4K20me1 interaction in a dose-dependent manner. UNC-926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC-926 for L3MBTL1 over 53BP1[1].
References:
[1]. Herold JM, et al. Structure–activity relationships of methyl-lysine reader antagonists. MedChemComm. 2012;3(45):45–51.
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