WAY-181187 (Synonyms: SAX-187) |
| Catalog No.GC39816 |
WAY-181187 (SAX-187) es un agonista completo del receptor 5-HT6 potente y selectivo con una Ki de 2,2 nM y una EC50 de 6,6 nM.
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Cas No.: 554403-49-5
Sample solution is provided at 25 µL, 10mM.
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WAY-181187 (SAX-187) is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM[1]. WAY181187 mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[2].
[1]. Lee E Schechter, et al. Neuropharmacological Profile of Novel and Selective 5-HT6 Receptor Agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33(6):1323-35. [2]. Teresa Riccioni, et al. ST1936 Stimulates cAMP, Ca2+, ERK1/2 and Fyn Kinase Through a Full Activation of Cloned Human 5-HT6 Receptors. Eur J Pharmacol. 2011 Jul 1;661(1-3):8-14.
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